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Aldactona (espironolactona) is a mild-acting diuretic, available in many countries around the world. In medicine, such drugs are used to treat hypertension, as they effectively reduce the retention of fluid and salts in the body. Aldactone reduces the amount of aldosterona (a hormone responsible for the balance of fluid in the body) produced by the adrenal glands. Este efeito é usado ativamente por fisiculturistas, que, por exemplo, precisam reduzir a quantidade de fluido subcutâneo durante a competição.

O que é diurético

For simplicity, a diurético can be defined as any product that increases the amount of urine (urine) released by the body.aldactona para acne De acordo com essa definição, um grande número de produtos diferentes chega, desde chás de ervas e decocções suaves e moderadas, até agentes químicos fortes que bombeiam fluidos e componentes minerais para fora do corpo.

The most common clinical use of diuretics is the treatment of hypertension (high blood pressure). They are also included in the medical indications for people suffering from edema (increased water retention in the body). In the past, many athletes who underwent a test for the use of illicit medicines previously used diuretics, trying to dilute their urine samples so that undesirable traces of forbidden compounds (such as anabolic steroids) became undetectable. This method really proved to be very effective in terms of doping control, but after a while, the vast majority of athletic organizations and federations added diuretics to the list of medicamentos proibidos para atletas. Esta circunstância praticamente excluiu a prática descrita acima do uso. Além disso, algumas federações que realizam testes para o uso de drogas ilícitas adicionam aos regulamentos anteriores a exigência de que o teor de água na amostra de urina para análise não exceda um certo nível estabelecido pelas regras do teste.

Another popular way of using diuréticos no esporte over the years has been to use these drugs in order to best pass the weight classification before competitions in such types as wrestling, weightlifting, boxing, etc. Indeed, the use of diuretics remains common in junior teams. It should be noted that most of the abusing diuretics are bodybuilders who use these medicines in an attempt to reduce the amount of water trapped under the skin.

Diuretics are used in courses in the período de pré-competição, sua recepção constante não é apropriada e perigosa. A recepção prolongada é acompanhada de complicações e, além disso, aumenta o decaimento da proteína, o que leva a uma diminuição da massa muscular.

Os diuréticos de plantas têm um efeito principal fracamente expresso e, portanto, não são usados ​​em esportes; na medicina, seu uso também é limitado.

Mecanismo de ação de diuréticos

Para entender o mechanism of action of diuretics, o conhecimento da anatomia e fisiologia dos rins é necessário, mas vamos tentar fazer isso em uma linguagem simples, suficiente para avaliar sua eficácia e o risco de efeitos colaterais.

Os rins filtram substâncias desnecessárias do sangue e, em particular, purificam-no do excesso de certos íons que formam eletrólitos. Os eletrólitos são fluidos internos do corpo (células, espaços intercelulares), que garantem o fluxo de reações bioquímicas no corpo em nível celular, graças ao qual o organismo vive.

It is the kidneys that function normally (ie, ensuring the correct balance of ions in the blood and cells), ensure the maintenance of pressão arterial normal. Os íons podem ser liberados na urina do sangue como resultado da filtração nos rins ou, inversamente, retornar ao sangue, dependendo da pressão arterial. Se for alto, mais íons serão removidos. Isto leva a uma diminuição da pressão arterial, uma vez que mais água é removida para a urina juntamente com íons.

de onde vem a agua?

The water that is removed in the urine is taken from the blood plasma (its water part), and into the plasma it comes from the space between the cells. It is this intercellular fluid that erases the alívio muscular, giving the muscles a flat look. What do diuretics do? They remove it. The mechanism of action of almost all diuretics is the same: eles estimulam a excreção de sódio.

Por que sódio?

Uma colher de chá de sal, que é conhecida por conter sódio, retém aproximadamente 2 litros de água no corpo. Se você remover o sódio do corpo, ele levará uma quantidade significativa de fluido.

É assim que os diuréticos agem: they prevent the passage of sodium through the filtering elements of the kidneys, it remains in the urine and is excreted when urinating. This is the reason for the colossal harm of diuretics.

História

Espironolactona was developed in the late 1950s and was first widely used in the 1960s. He filled an important niche of potassium-sparing diuretics, which less affect the electrolyte balance of the body. In many respects, it is regarded as safe and mild, compared with loop diuretics or thiazides. Espironolactona is now very common in the world, sold under different brands and also is part of the combined preparations with other diuretics.

Formulários do produto

Espironolactona is available in the form of tablets of 25 mg.

Características estruturais

Espironolactona is an aldosterone antagonist and diuretic. Its chemical formula is 17-hydroxy-7alpha-mercapto-3oxo-17alpha-pregn-4-ene-21-carboxylic acid, y-lactone acetate.

Safety of Aldactone

O abuse of diuretics for the purpose of forming a physique has a high degree of risk. Diuretics can cause a vida-Aldactonanível ameaçador de desidratação and electrolyte imbalance in appointments without proper medical supervision. Many deaths are associated with the abuse of these drugs. It is important to note that potassium supplements or a diet rich in potassium are not recommended when taking potassium-sparing diuretics such as espironolactona. Excessive intake of potassium can lead to hyperkalemia, impaired cardiac function and death.

This tool is considered one of the safest, so it is very suitable for use by novice athletes. Acquainted with the ação de Aldactone and planning to achieve more significant results, you can additionally use thiazide or furosemide (Lasix). In this case, it is possible to avoid an overdose, in contrast to the cases of taking one of these means.

This combination will provide a faster fluid withdrawal with less loss of calcium or potassium. In combination with hydrochlorothiazide, we can reduce the dose de Aldactone by half (from 100 mg) and add the same amount of thiazide. The combination of 50 mg per 50 mg will greatly accelerate the withdrawal of fluid without the appearance of side effects. Thiazide balances the absorption of potassium, so this dosage will not affect the level of potassium in the body. On the other hand, Lasix (furosemide) is a more effective component in combinação com Aldactone.

A very popular approach in this case, to start taking, lowering the dose de Aldactone to 50 mg and by adding 20 mg of Lasix orally, which will ensure fluid withdrawal as in the case of taking the Lasix 40 mg tablet. The destructive effect of Lasix on potassium is neutralized by Aldactona, so there is no need to take any additional funds. In Europe, this combinação de diuréticos is always on sale and very popular among atletas.

Side effects of Aldactone

Os efeitos colaterais incluem: gynecomastia , spasms, diarrhea, drowsiness, headache, skin irritation, rash, confusion, impotence, loss of coordination, menstrual irregularities, virilization. It can also have some propriedades anti-androgênicas.

Recepção de Aldactone

When used for sporting purposes, the usual dosage is 100mg in the morning for 3-5 days before the competition. In women, it can be used as an anti-androgen in a dose of 25-75 mg per day for 1-2 weeks. When combined with other diuretics, the dose of both drugs should be reduced by half.

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