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Methyltrienolone was originally created as a veterinary drug for female dogs, it had to keep them under control during heat, by interrupting the cycle of ovulation. With special care, breeders could regulate the cycles of their own bitches. Eventually, athletes started using it to raise aggression before the competition. There is even a well-known rumor that Mike Tyson was just under Chek-Drops when he bit off Holyfield’s ear, right during the fight. But somehow, later the great guru Dan Dushein found the use of Chek-Drops in modern bodybuilding long before that. Drops was removed from the assembly line and put again several times before he gained wide popularity in serious fighters’ circles.
Has a weaker analog of metribolone, also known as methyltrienolone or R1881, which is a 17-methylated derivative of trenbolone. Metribolone has a lower selectivity to androgen receptors compared to mibolerone.
- Molecular weight: 302, 455
- Molecular formula: C2O-H3O-O2
- Boiling point: not known
- Production: Upjohn, Supra
- Start-up: (Started and withdrawn from production several times)
- Effective dose: 200-400 μg
- Half-life: 2-4 hours
- Time of detection: immediately after admission
- Estrogenic activity: has antiestrogenic properties
- Progestic activity: yes
- Androgenic anabolic index: 250: 590
Methyltrienolone was first described in 1965. It is one of the most powerful anabolic steroids that has never been sold in pharmacies. This drug was used only in laboratory studies. Studies were conducted in the context of breast cancer treatment in the 1960s and 1970s. He slowed down, and in some cases reversed the process of tumor growth. Studies continued for a short time, because of the revealed toxicity. In the mid-1970s, methyltrinolone was tested in animals to determine binding to androgen receptors. He was very suitable for this purpose. His activity and resistance to binding blood proteins allowed him to easily become a reference substance. Because of its resistance to metabolism, metabolites of methyltrinolone did not interfere with the results of most experiments.
Methyltrienolone is a modified form of nandrolone. It is different:
- the addition of methyl groups to carbon 17a-alpha to protect the hormone during oral administration and
- the introduction of double bonds on carbon atoms 9 and 11, which increases its affinity and slows metabolism.
The resulting steroid is significantly more potent than its nandrolone base, and in comparison has a much longer half-life and a lower affinity for the whey proteins. Methyltrinolone chemically differs from trenbolone only by adding a methyl group to c-17. This significantly changes the activity of Methyltrinolone, so the drug can not be considered simply an oral form of trenbolone.
Side effects of Methyltrienolone
Methyltrienolone does not aromatize and does not have estrogenic activity, but it can cause progesterone pimples, which can contribute to the development of gynecomastia, inhibition of endogenous testosterone production, and growth of the fatty layer. Methyltrienolone is the most powerful androgen and the occurrence of androgenic side effects is very likely, they include skin greasiness, acne, facial and body hair growth. In women, the emergence of virilizing side effects, so he categorically is contraindicated. Since methyltrienolone is a 17-alpha alkylated drug, it is hepatotoxic for the liver. The intake of methyltrinolone in the injectable form is several times more effective and also several times safer for the liver. This is due to the fact that he passes the first pass through the liver, in contrast to the oral form. The drug is not recommended for use for more than 4 weeks. There is also a suppression of the production of endogenous testosterone. Without any intervention in stimulating the development of his testosterone, he will return to the natural level 1-4 months after the course.
Side effects (estrogenic)
Methyltrinolone does not aromatize in the body, and does not show significant estrogenicity. It should be noted, however, that Methyltrinolone has a significant affinity for the receptors of progesterone. Side effects associated with progesterone are similar to estrogen, and include a slowdown in the production of testosterone and an increase in the rate of fat accumulation. Progestins also increase the stimulating effect of estrogens on the growth of breast tissue. Between these two hormones there is such a strong interaction that gynecomastia can occur with the help of a progestin even in the absence of excessive levels of estrogen. Often, to mitigate the symptoms of gynecomastia caused by this steroid, it is sufficient to use an anti-estrogen that inhibits the estrogen components of this disorder.
Side Effects (androgenic)
Although a steroid is classified as an anabolic, androgenic side effects when used with this substance manifest themselves quite often, and can include such manifestations as increased sebaceous glands, acne and hair growth on the body / face. Anabolic / androgenic steroids can also aggravate male pattern baldness. Women should be aware of the potential virilizing effects of anabolic / androgenic steroids. They can include: deepening of the voice, irregular menstrual cycle, changes in the texture of the skin, growth of facial hair and an increase in the clitoris. In addition, the enzyme 5-alpha-reductase does not metabolize Methyltrinolone, so its relative androgenicity does not depend on the use of Finasteride or Dutasteride.
Side effects (hepatotoxicity)
Methyltrinolone is a c17-alpha alkaline compound. This protects the drug from deactivation in the liver, allowing a very high percentage of it to enter the bloodstream after ingestion. C17-alpha alkaline anabolic / androgenic steroids can be hepatotoxic. Prolonged exposure or high dosages can provoke liver damage. In rare cases, life-threatening dysfunction may develop. It is advisable periodically during each cycle to visit a doctor to monitor liver function and overall health. The intake of c17-alpha-alkylated steroids is usually limited to 6-8 weeks, which avoids the escalation of liver strains. Methyltrinolone is an extremely potent oral steroid, with a very high level of resistance to metabolism in the liver. This makes its use extremely toxic to the liver, which excludes its use as a prescription drug. Studies published by the University of Bonn in Germany back in 1966, demonstrated this in some detail. In fact, at this time the researchers considered this steroid to be the most toxic to the liver among all the drugs ever studied in humans, and pointed out that: “Methyltrinolone … is an orally active anabolic at doses less than 1.0 mg per day in healthy adults, and was tested due to his influence on liver function. When measuring several parameters (confinement of plasma proteins, total bilirubin level, activity of transaminases, alkaline phosphatase and cholinesterase in serum, activity of proaccelerin in plasma) Methyltrinolone has proved to be a very active drug that causes biochemical symptoms of intrahepatic cholestasis …. Thus, Methyltrinolone is the most “hepatotoxic steroid”. When using any hepatotoxic anabolic / androgenic steroids, it is recommended to take such additives for liver detoxification as Liver Stabil, Liv-52, or Essential Forte.
Reception of Methyltrienolone
Studies have shown that taking oral AAS along with food reduces the bioavailability of the drug. This is caused by the fat-soluble nature of AAS, which can allow part of the drug to dissolve in fat from food, which will reduce the absorption of AAS in the gastrointestinal tract. For maximum effect this drug should be taken on an empty stomach.
Admission (for men)
Methyltrienolone has not been approved for use in humans. This drug is not recommended for improving the physical form because of its high hepatotoxicity. Those who really want to use this drug should take their toxicity seriously. Regular blood tests are necessary to ensure that the drug does not damage the liver. Do not use for more than 4 weeks. For an obvious anabolic effect, 0.5 mg of the drug is sufficient. Dosages can range from 0.5 mg to 2 mg per day. It must be stressed once again that there are many safer drugs. Methyltrienolone – this is the drug that is best left alone.
Admission (for women)
Methyltrienolone is not recommended for women because of its extremely strong toxicity and the tendency to cause virilization phenomena.
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