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Human chorionic gonadotropin (HCG) is a hormone that is produced by the placenta during pregnancy, and then unchanged in urine, from which it is extracted and purified to produce drugs. Chorionic gonadotropin has the same biological effects as luteinizing hormone (gonadotropin hormone or gonadotropin), which is formed in the pituitary gland. You can easily buy in pharmacies without a prescription.
Recent studies have shown complete ineffectiveness of the use of this drug when ingested as part of food additives. In the United States of 06.12.2011, medicines and nutritional supplements containing HCG are banned.
Chorionic gonadotropin in the chemical structure is a glycoprotein consisting of two subunits: alpha and beta. The α-subunit of CG is completely homologous to the α-subunits of luteinizing, follicle-stimulating and thyroid-stimulating hormones. The β-subunit of HG is unique for this hormone and distinguishes it from LH, FSH and TSH.
Chorionic gonadotropin consists of 237 amino acids and has a molecular weight of 36.7 kilodaltons.
Chorionic gonadotropin possesses the biological properties of both LH and FSH, and binds to both types of receptors for gonadotropins, but luteinizing activity in CG significantly predominates over follicle-stimulating activity. HG on luteinizing activity significantly exceeds the “usual” LH produced by the anterior pituitary gland.
It is through the secretion of significant amounts of HG in the fetal placenta that the yellow body, normally existing for about 2 weeks during each menstrual cycle, does not undergo resorption in pregnant women and remains functionally active for 10-12 weeks until the placenta is able to produce itself estrogen and progesterone. Moreover, the yellow body of pregnant women under the influence of HG produces very large amounts of progesterone, physiologically impossible in normal in the nonpregnant organism. Also, HG stimulates the production of estrogens and weak androgens by the follicular apparatus of the ovaries.
To some extent, HG also appears to have corticotropic properties, increasing steroidogenesis in the adrenal cortex and promoting functional hyperplasia of the adrenal cortex in a pregnant woman. Increased secretion of glucocorticoids under the influence of HG can play a role in the mechanisms of adaptation of the pregnant woman to stress, such as pregnancy, and also provides the physiological immunosuppression necessary for the development of a genetically half-foreign organism inside the uterus. In this regard, it is worth noting that the pituitary gonadotropins do not possess corticotropic properties.
Chorionic gonadotropin also plays a role in the development and maintenance of the functional activity of the placenta itself, improves its trophism and helps increase the number of chorionic villi.
In the nonpregnant organism, normal HG is absent, but it is often produced by various malignant tumors (ectopic HG production).
The introduction of exogenous CG in women in the middle of the cycle causes, in addition to increasing the production of estrogens and progesterone in the ovaries, ovulation, and then luteinization of the burst follicle, and further supports the function of the yellow body.
In men, exogenous HG stimulates spermatogenesis and production of sex hormones.
A pharmacy pregnancy test is based on determining the presence of chorionic gonadotropin in the urine. More accurate is the quantitative determination of hCG in the blood.
- Chorionic gonadotropin
- Stimulates the synthesis of sex hormones in the testicles, so it has the same spectrum of effects as testosterone.
- Stimulates spermatogenesis.
- Strengthens the development of genital organs and secondary sexual characteristics.
- In women, it stimulates progesterone production by the yellow body, provokes ovulation, supports the development of the placenta.
Physiology of gonadotropin
In the body, the regulation of the gonadotropin level occurs according to the feedback mechanism in the hypothalamic-pituitary-testicular axis:
- Gnadoliberin is produced in the hypothalamus and stimulates the release of gonadotropic hormones.
- Gonadotropins are produced in the pituitary gland and normally stimulate the testicles, with their lack of testicular atrophy.
- Testosterone and anabolic steroids inhibit the production of gonadoterin and gonadotropins, resulting in atrophy of the testicles.
- Thus, in bodybuilding, with prolonged use of anabolic steroids, it is necessary to additionally administer gonadotropic hormone (chorionic gonadotropin) in order to prevent testicular atrophy.
The use of HCG in bodybuilding
In bodybuilding, perhaps, there is only one property of gonadotropin, an increase in the secretion of sex hormones (testosterone) by the testicles. As a result, gonadotropin is used as a means for preventing testicular atrophy and as a component of PCT.
The use of HCG for anabolic purposes is not justified and dangerous for health. First, because the chorionic gonadotropin is less effective than anabolic steroids. Secondly, to obtain a good effect, it is necessary to use it in large doses (more than 4000 IU per week), which can cause irreversible disturbances in the physiological axis of the hypothalamus-pituitary-testicle. In connection with this circumstance, many articles negatively speak about HCG, forgetting about its true purpose.
The use of chorionic gonadotropin on the course and PCT
In bodybuilding, the use of chorionic gonadotropin is justified and even necessary during the course of anabolic steroids for the prevention of testicular atrophy. In this case, its use is safe, since the dose of the drug is much lower, in addition, the chorionic gonadotropin can eliminate some side effects of anabolic steroids, as well as retain the typed muscle mass. HCG is particularly important if the steroid cycle is greater than 6 weeks or when large doses are used. In this situation, the chorionic gonadotropin does not disrupt the hypothalamic-pituitary-testicular axis, and, most importantly, allows the function of the testicles to be maintained.
Less commonly, chorionic gonadotropin is used in post-course therapy. Many believe that it should be administered before PCT, since during post-course therapy, hCG may interfere with recovery.
Gonadotropin for weight loss
A relatively recent study of the British scientist – endocrinologist A.T.W. Simeons, in which it is claimed that chorionic gonadotropin can be used for weight loss in order to maintain muscle mass. The scientist believes that the gonadotropin programs the hypothalamus on the expenditure of fat stores, while the muscles remain protected from catabolism. Simeons recommends the use of small (and therefore safe) doses of HCG-125 ME daily against a low-calorie diet – less than 1500 calories per day. This diet is practiced in many specialized centers for weight loss. It should be noted that during this course it is necessary to consume a sufficient amount of protein and vitamins.
When taking HCG, you may experience the same side effects as when taking testosterone. The use of gonadotropin in large doses or for a long time leads to suppression of the secretion of gonadotropin-releasing hormone, in connection with which the function of the physiological axis of the hypothalamus-hypophysis-testicle is disrupted. The information that gonadotropin can lead to symptoms of pregnancy in men is absurd and not true.
Reviews of the chorionic gonadotropin (HCG)
On the forums of bodybuilders, positive reviews about gonadotropin predominate when using it at PCT and during lengthy and lengthy courses of anabolic steroids. The use of hCG is justified only for men. Chorionic gonadotropin is not used in female courses, and is not a means for “treating” the effects of aromatization.
Negative reviews of the chorionic gonadotropin hCG can be found in small numbers, as it is rarely used for anabolic purposes. Usually such people write, trying with the help of pharmacy pharmacology to increase 10 kg of muscles per course, and at the same time lose weight. The drug does not make sense to forge, because it is in free sale.
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