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Aldactone (spironolattone) is a mild-acting diuretic, available in many countries around the world. In medicine, such drugs are used to treat hypertension, as they effectively reduce the retention of fluid and salts in the body. Aldactone reduces the amount of aldosterone (a hormone responsible for the balance of fluid in the body) produced by the adrenal glands. Questo effetto è attivamente utilizzato dai bodybuilder, che, ad esempio, ha bisogno di ridurre la quantità di fluido sottocutaneo durante la competizione.

Cos'è il diuretico

For simplicity, a diuretico can be defined as any product that increases the amount of urine (urine) released by the body.aldactone per l'acne Sotto questa definizione, arriva un gran numero di prodotti diversi, che vanno da tisane e decotti a base di erbe morbide e moderate, fino a forti agenti chimici che pompano fuori dal corpo componenti fluidi e minerali.

The most common clinical use of diuretics is the treatment of hypertension (high blood pressure). They are also included in the medical indications for people suffering from edema (increased water retention in the body). In the past, many athletes who underwent a test for the use of illicit medicines previously used diuretics, trying to dilute their urine samples so that undesirable traces of forbidden compounds (such as anabolic steroids) became undetectable. This method really proved to be very effective in terms of doping control, but after a while, the vast majority of athletic organizations and federations added diuretics to the list of medicinali proibiti per gli atleti. Questa circostanza praticamente escludeva la pratica sopra descritta dall'uso. Inoltre, alcune delle federazioni che praticano test per l'uso di droghe illecite aggiungono ai regolamenti precedenti il ​​requisito che il contenuto di acqua nel campione di urina per l'analisi non superi un determinato livello stabilito dalle regole del test.

Another popular way of using diuretici nello sport over the years has been to use these drugs in order to best pass the weight classification before competitions in such types as wrestling, weightlifting, boxing, etc. Indeed, the use of diuretics remains common in junior teams. It should be noted that most of the abusing diuretics are bodybuilders who use these medicines in an attempt to reduce the amount of water trapped under the skin.

Diuretics are used in courses in the periodo pre-competizione, la loro costante ricezione non è appropriata e pericolosa. La ricezione prolungata è accompagnata da complicanze e, inoltre, aumenta il decadimento delle proteine, che porta ad una diminuzione della massa muscolare.

I diuretici delle piante hanno un effetto principale debolmente espresso e non sono quindi utilizzati nello sport, in medicina anche il loro uso è limitato.

Meccanismo d'azione di diuretici

Per capire il mechanism of action of diuretics, è richiesta la conoscenza dell'anatomia e della fisiologia dei reni, ma cercheremo di farlo in un linguaggio semplice sufficiente a valutare la loro efficacia e il rischio di effetti collaterali.

I reni filtrano sostanze non necessarie dal sangue e, in particolare, lo purificano dall'eccesso di certi ioni che formano gli elettroliti. Gli elettroliti sono fluidi interni del corpo (cellule, spazi intercellulari), che assicurano il flusso di reazioni biochimiche nel corpo a livello cellulare, grazie alle quali vive l'organismo.

It is the kidneys that function normally (ie, ensuring the correct balance of ions in the blood and cells), ensure the maintenance of pressione sanguigna normale. Gli ioni possono essere rilasciati nelle urine dal sangue a seguito della filtrazione nei reni o, al contrario, tornare al sangue, a seconda della pressione sanguigna. Se è alto, vengono rimossi più ioni. Questo porta ad una diminuzione della pressione sanguigna, dal momento che più acqua viene rimossa dalle urine insieme agli ioni.

Da dove viene l'acqua?

The water that is removed in the urine is taken from the blood plasma (its water part), and into the plasma it comes from the space between the cells. It is this intercellular fluid that erases the sollievo muscolare, giving the muscles a flat look. What do diuretics do? They remove it. The mechanism of action of almost all diuretics is the same: stimolano l'escrezione di sodio.

Perché il sodio?

Un cucchiaino di sale, che è noto per contenere il sodio, mantiene circa 2 litri di acqua nel corpo. Se rimuovete il sodio dal corpo, quindi con esso ci vorrà una quantità significativa di liquido.

Ecco come agiscono i diuretici: they prevent the passage of sodium through the filtering elements of the kidneys, it remains in the urine and is excreted when urinating. This is the reason for the colossal harm of diuretics.

Cronologia

Spironolattone was developed in the late 1950s and was first widely used in the 1960s. He filled an important niche of potassium-sparing diuretics, which less affect the electrolyte balance of the body. In many respects, it is regarded as safe and mild, compared with loop diuretics or thiazides. Spironolattone is now very common in the world, sold under different brands and also is part of the combined preparations with other diuretics.

Forme del prodotto

Spironolattone is available in the form of tablets of 25 mg.

Caratteristiche strutturali

Spironolattone is an aldosterone antagonist and diuretic. Its chemical formula is 17-hydroxy-7alpha-mercapto-3oxo-17alpha-pregn-4-ene-21-carboxylic acid, y-lactone acetate.

Safety of Aldactone

La abuse of diuretics for the purpose of forming a physique has a high degree of risk. Diuretics can cause a vita-Aldactonelivello minaccioso di disidratazione and electrolyte imbalance in appointments without proper medical supervision. Many deaths are associated with the abuse of these drugs. It is important to note that potassium supplements or a diet rich in potassium are not recommended when taking potassium-sparing diuretics such as spironolattone. Excessive intake of potassium can lead to hyperkalemia, impaired cardiac function and death.

This tool is considered one of the safest, so it is very suitable for use by novice athletes. Acquainted with the azione di Aldactone and planning to achieve more significant results, you can additionally use thiazide or furosemide (Lasix). In this case, it is possible to avoid an overdose, in contrast to the cases of taking one of these means.

This combination will provide a faster fluid withdrawal with less loss of calcium or potassium. In combination with hydrochlorothiazide, we can reduce the dose di Aldactone by half (from 100 mg) and add the same amount of thiazide. The combination of 50 mg per 50 mg will greatly accelerate the withdrawal of fluid without the appearance of side effects. Thiazide balances the absorption of potassium, so this dosage will not affect the level of potassium in the body. On the other hand, Lasix (furosemide) is a more effective component in combinazione con Aldactone.

A very popular approach in this case, to start taking, lowering the dose di Aldactone to 50 mg and by adding 20 mg of Lasix orally, which will ensure fluid withdrawal as in the case of taking the Lasix 40 mg tablet. The destructive effect of Lasix on potassium is neutralized by Aldactone, so there is no need to take any additional funds. In Europe, this combinazione di diuretici is always on sale and very popular among gli atleti.

Side effects of Aldactone

Gli effetti collaterali includono: gynecomastia , spasms, diarrhea, drowsiness, headache, skin irritation, rash, confusion, impotence, loss of coordination, menstrual irregularities, virilization. It can also have some proprietà anti-androgeni.

Ricevimento Aldactone

When used for sporting purposes, the usual dosage is 100mg in the morning for 3-5 days before the competition. In women, it can be used as an anti-androgen in a dose of 25-75 mg per day for 1-2 weeks. When combined with other diuretics, the dose of both drugs should be reduced by half.

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