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Aldactone (spironolactone) is a mild-acting diuretic, available in many countries around the world. In medicine, such drugs are used to treat hypertension, as they effectively reduce the retention of fluid and salts in the body. Aldactone reduces the amount of aldostérone (a hormone responsible for the balance of fluid in the body) produced by the adrenal glands. Cet effet est activement utilisé par les bodybuilders, qui, par exemple, ont besoin de réduire la quantité de liquide sous-cutané pendant la compétition.

Qu'est-ce que Diuretic

For simplicity, a diurétique can be defined as any product that increases the amount of urine (urine) released by the body.aldactone pour l'acné Selon cette définition, un grand nombre de produits différents entrent en jeu, allant des tisanes et décoctions tièdes et modérées, jusqu'aux agents chimiques puissants qui pompent les composants liquides et minéraux hors du corps.

The most common clinical use of diuretics is the treatment of hypertension (high blood pressure). They are also included in the medical indications for people suffering from edema (increased water retention in the body). In the past, many athletes who underwent a test for the use of illicit medicines previously used diuretics, trying to dilute their urine samples so that undesirable traces of forbidden compounds (such as anabolic steroids) became undetectable. This method really proved to be very effective in terms of doping control, but after a while, the vast majority of athletic organizations and federations added diuretics to the list of médicaments interdits pour les athlètes. Cette circonstance a pratiquement exclu la pratique décrite ci-dessus de l'utilisation. De plus, certaines des fédérations pratiquant des tests pour l'usage de drogues illicites ajoutent aux règlements précédents l'exigence que la teneur en eau de l'échantillon d'urine à analyser n'excède pas un certain niveau établi par les règles d'essai.

Another popular way of using diurétiques dans les sports over the years has been to use these drugs in order to best pass the weight classification before competitions in such types as wrestling, weightlifting, boxing, etc. Indeed, the use of diuretics remains common in junior teams. It should be noted that most of the abusing diuretics are bodybuilders who use these medicines in an attempt to reduce the amount of water trapped under the skin.

Diuretics are used in courses in the période de pré-compétition, leur réception constante n'est pas appropriée et dangereuse. La réception prolongée s'accompagne de complications et, de plus, la dégradation des protéines augmente, ce qui entraîne une diminution de la masse musculaire.

Les diurétiques végétaux ont un effet principal faiblement exprimé et ne sont donc pas utilisés dans les sports, en médecine leur utilisation est également limitée.

Mécanisme d'action des diurétiques

Pour comprendre le mechanism of action of diuretics, la connaissance de l'anatomie et de la physiologie des reins est nécessaire, mais nous essaierons de le faire dans un langage simple suffisant pour évaluer leur efficacité et le risque d'effets secondaires.

Les reins filtrent les substances inutiles du sang et, en particulier, le purifient de l'excès de certains ions qui forment des électrolytes. Les électrolytes sont des fluides internes du corps (cellules, espaces intercellulaires), qui assurent le flux des réactions biochimiques dans le corps au niveau cellulaire, grâce à quoi vit l'organisme.

It is the kidneys that function normally (ie, ensuring the correct balance of ions in the blood and cells), ensure the maintenance of une pression artérielle normale. Les ions peuvent être libérés dans l'urine du sang à la suite d'une filtration dans les reins ou, inversement, retourner dans le sang, en fonction de la pression sanguine. Si elle est élevée, plus d'ions sont retirés. Cela conduit à une diminution de la pression artérielle, car plus d'eau est éliminée dans l'urine avec des ions.

D'où provient l'eau?

The water that is removed in the urine is taken from the blood plasma (its water part), and into the plasma it comes from the space between the cells. It is this intercellular fluid that erases the soulagement musculaire, giving the muscles a flat look. What do diuretics do? They remove it. The mechanism of action of almost all diuretics is the same: ils stimulent l'excrétion de sodium.

Pourquoi le sodium?

Une cuillère à café de sel, qui contient du sodium, retient environ 2 litres d'eau dans le corps. Si vous enlevez le sodium du corps, alors avec cela prendra une quantité significative de liquide.

C'est comme ça que les diurétiques agissent: they prevent the passage of sodium through the filtering elements of the kidneys, it remains in the urine and is excreted when urinating. This is the reason for the colossal harm of diuretics.

Histoire

Spironolactone was developed in the late 1950s and was first widely used in the 1960s. He filled an important niche of potassium-sparing diuretics, which less affect the electrolyte balance of the body. In many respects, it is regarded as safe and mild, compared with loop diuretics or thiazides. Spironolactone is now very common in the world, sold under different brands and also is part of the combined preparations with other diuretics.

Formulaires de produit

Spironolactone is available in the form of tablets of 25 mg.

Caractéristiques structurelles

Spironolactone is an aldosterone antagonist and diuretic. Its chemical formula is 17-hydroxy-7alpha-mercapto-3oxo-17alpha-pregn-4-ene-21-carboxylic acid, y-lactone acetate.

Safety of Aldactone

Les abuse of diuretics for the purpose of forming a physique has a high degree of risk. Diuretics can cause a la vie-Aldactoneniveau menaçant de déshydratation and electrolyte imbalance in appointments without proper medical supervision. Many deaths are associated with the abuse of these drugs. It is important to note that potassium supplements or a diet rich in potassium are not recommended when taking potassium-sparing diuretics such as spironolactone. Excessive intake of potassium can lead to hyperkalemia, impaired cardiac function and death.

This tool is considered one of the safest, so it is very suitable for use by novice athletes. Acquainted with the action d'Aldactone and planning to achieve more significant results, you can additionally use thiazide or furosemide (Lasix). In this case, it is possible to avoid an overdose, in contrast to the cases of taking one of these means.

This combination will provide a faster fluid withdrawal with less loss of calcium or potassium. In combination with hydrochlorothiazide, we can reduce the dose d'Aldactone by half (from 100 mg) and add the same amount of thiazide. The combination of 50 mg per 50 mg will greatly accelerate the withdrawal of fluid without the appearance of side effects. Thiazide balances the absorption of potassium, so this dosage will not affect the level of potassium in the body. On the other hand, Lasix (furosemide) is a more effective component in combinaison avec Aldactone.

A very popular approach in this case, to start taking, lowering the dose d'Aldactone to 50 mg and by adding 20 mg of Lasix orally, which will ensure fluid withdrawal as in the case of taking the Lasix 40 mg tablet. The destructive effect of Lasix on potassium is neutralized by Aldactone, so there is no need to take any additional funds. In Europe, this combinaison de diurétiques is always on sale and very popular among athlètes.

Side effects of Aldactone

Les effets secondaires incluent: gynecomastia , spasms, diarrhea, drowsiness, headache, skin irritation, rash, confusion, impotence, loss of coordination, menstrual irregularities, virilization. It can also have some propriétés anti-androgènes.

Réception Aldactone

When used for sporting purposes, the usual dosage is 100mg in the morning for 3-5 days before the competition. In women, it can be used as an anti-androgen in a dose of 25-75 mg per day for 1-2 weeks. When combined with other diuretics, the dose of both drugs should be reduced by half.

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