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This article is an attempt to describe the purpose of anabolic / androgenic steroids and their modes of action on the human body by language available to non-professionals. Our goal is to make a general overview of steroids, not focusing on the description of any particular of them. Of course, the author does not approve the use of steroids by anyone, not under the supervision and not under the supervision of a qualified medical specialist.
Types of Steroids
Anabolic steroids can be roughly divided into two types: oral and injectable. When you take something (drugs or food) through the mouth, the vast majority of the substances contained in them pass through the liver before reaching the mainstream. Therefore, Injectable Steroids are not suitable for oral administration, since the liver deactivates steroids already when they “first pass” through it with blood from the intestine (“the second passage” of blood through the liver is carried out by the portal vein with the products of vital activity). The essence of deactivation is the addition of one or more hydroxyl groups to the steroid molecule, which increases its solubility in water and facilitates excretion from the human body with urine.
Injectable steroids preparations are very well excreted from the blood in just one pass through the liver. But if so, then is there any sense in injecting? How effective are they? The answer is called “depot” (or tank). That is, in the human body with the help of an Injectable Steroids a “storehouse” of steroids is created, from which they regularly enter into the blood. As the steroid is removed from the bloodstream in the liver, a new amount of the steroid drug is released into the blood from the depot. There are several ways to create such tanks.
Acetate trenbolone is an excellent choice if you have set yourself the task of getting rid of excess fat mass and in parallel to gain quality. Also, with this injectable anabolic steroid, you will increase your strengths, and your muscles will gain additional relief.
Acetate of trenbolone is a modern AAS, possessing great power and high quality. He is worthy to learn about him as much as possible. Here are the effects that this anabolic possesses:
- The whole course you will gain quality muscle mass;
- Quickly get rid of a large number of subcutaneous fat deposits;
- Excess fluid is removed from the cellular structure of the tissues;
- The muscles will become firm;
- The speed of production of amino acid compounds in tissues will dramatically increase;
- The rate of metabolic processes will increase;
- Significantly reduce the time spent by the body for recovery after classes.
I also want to say that injectable anabolic injectable steroids from Vermoja company, in comparison with other analogues, affect the body 20 percent longer.
One of the most powerful injectable drugs is deca-durabolin. As a working component in the deck is used nandrolone decanoate, which is used by athletes for several decades. All this time, the steroid shows excellent results, and its popularity only increases.
Decanoate nandrolone is a very powerful steroid, which is noted by all athletes. When using this AAS in your course, you will receive the following effects:
- Rapid recruitment of a large number of muscle tissues with a delay in it of all nutrients and fluids;
- Your potential will increase significantly, which will open before you the opportunity to use a large working weight of sports equipment and increase the intensity of their training;
- Exchange processes in the body will accelerate dramatically, which against a background of high anabolism will inevitably lead to a set of muscle mass.
Transportation of injectable steroids with blood
As soon as the steroid is released from the depot (or oral steroid is absorbed in the intestine), its transportation begins with blood. Protein-carriers (albumin and sex hormone globulin) bind about 98% of testosterone present in the blood in vivo. Thus, only 2% of this hormone is free, and can participate in any processes. When an exogenous (introduced) steroid appears in a person’s blood, the level of a free steroid becomes significantly higher than 2%.
Keep in mind that the hormone is not constantly associated with some of the proteins, but the process of continuous formation and destruction of such bonds is taking place, and at the same time, approximately 2% of the hormone is in an unbound, natural state. But if you imagine that somehow these 2% of the unbound hormone suddenly disappear, then the proteins will release more of the hormone in order to compensate for the shortage. Blood is the transport mechanism through which hormones are delivered to their target tissues (muscles).
Activation of androgen receptors
As soon as the free molecule of the steroid reaches the muscle cell, it diffuses into it. In this case, such penetration can be carried out with or without transport protein. Once inside the cell, the AAS moves in the direction of the cell nucleus, where the steroid can contact the androgen receptor (AR), and activate it. The two receptor complexes thus activated are combined to form an androgen response element (EAO). Further, EAO interacts with DNA in the nucleus and increases the transcription (copying) of some genes (eg, muscle protein genes). And this will happen as long as the EAO remains intact. It must be remembered, however, that AAS and receptors are in a state of constant change in their connection, which then arises, then disappears, in a manner similar to that of the carrier proteins discussed above. The effect of EAO can stop if it simply loses one of the two AASs associated with the AR receptors. This explains why 1 gram per week of testosterone is more effective than its 1/2 gram a week, although 1/2 gram seems to contain more than enough AAS to bind all the APs in the human body. A higher concentration of AAS molecules increases the likelihood that most APs will contact them, and the average amount of EAO will remain unchanged for a longer period of time.
Activation of the androgen receptor is a key mechanism in the action of AAS. However, this mechanism alone can not explain the differences between injectable steroids. So, for example, nandrolone (nandrolone) activates AP better than testosterone, but to a lesser extent it helps to increase muscle mass. When we talk about “other actions”, first of all we mean the impact on the central nervous system: increased motor and muscle activity and coordination, a change in mood (ie, the appearance of energy, pressure, and even some aggressiveness). The mechanism by which AAS causes such phenomena is not yet well understood at the present time. Also one of the effects that occurs in the liver, and is caused by some steroids, is the “release” of certain growth factors. All of the above “other actions” of steroids explain why the simultaneous application of two different types of AAC is often better than one single.
Removal of steroids from the body
The liver is the main way of decontamination of steroids. Here their chemical structure changes, as a result of which they become soluble in water and capable of excretion through the kidneys. At the same time, significant amounts of many steroids are eliminated from the body without undergoing any changes in the liver, or with the formation of water-soluble sulfates. Many doctors believe that AAS can cause damage to the liver, because when they are used, there is an increase in the blood of enzymes AST and ALT. It is known that elevated levels of these enzymes are observed in patients with liver damage in certain diseases, so it can be concluded that AAS also causes liver damage, judging by the level of AST and ALT. Recent work of scientists, however, showed that the true marker of liver damage is the enzyme GGT. But its level remains unchanged when using some of the AAC. So, it still remains a question: does all AAS really harm the liver? At the same time, it has been established that 17 alpha-alkylated AASs can actually damage the liver in some rare cases, and that this effect is reversible and disappears after discontinuing the use of injectable steroids. Fears often arise about the possibility of AAS to harm the kidneys, but it is also unlikely.
The only thing that can be said is that 1 gram, maybe even better than 500 mg, but the possibility of side effects while also certainly increase. As stated above, “500 mg seems to be more than enough to saturate all the AP bonds in the body.” After you enter the drug in more than what your receptors can “handle”, the chances of side effects are getting high enough.
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