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Dutasteride (Avodart) is an inhibitor of 5-a redactase, which is an enzyme responsible for converting testosterone to dihydrotestosterone. This drug is able to significantly reduce the serum concentration of dihydrotestosterone, thereby reducing the undesirable androgenic effects caused by its presence. Effective quickly, one tablet of 1 mg reduces the concentration of dihydrotestosterone by 65% in 24 hours. For medical purposes, this drug is used to treat two diseases. First Dutasteride was produced in the US under the name of Proscar and was used in patients with benign prostatic hyperplasia (prostate enlargement). Recently (in December 1997) Avodart was approved for the treatment of alopecia. Now there is another trade name for the drug, Propecia, which is the same drug, but only one tablet contains 1/5 of ProscarXCHARXs dose. For a long time, scientists believed that the cause of male pattern baldness was only dihydrotestosterone (along with genetic factors), so after the release of Proscar, there was little doubt that Dutasteride (Avodart) would be used for this purpose. This was a breakthrough for men suffering from baldness.
Dutasterida y culturismo
Due to its specific nature Dutasteride does not have a big influence on other hormones in the body. It is not bound to the androgen receptor and does not possess androgenic, antiandrogenic, estrogenic or antiestrogenic properties. It should not affect the level of cortisol, thyroid stimulating hormone, or thyroxine, and should not change the level of colesterol de lipoproteínas de alta densidad o baja densidad. Changes in luteinizing or follicle-stimulating hormones are insignificant, this drug does not affect the hypothalamic-pituitary-testicular system. In a small number of cases, a decrease in the level of dihydrotestosterone caused sexual disorders. Although complaints were not frequent, this problem can be quickly resolved by stopping the drug. Interestingly, Avodart increases the level of testosterone by 15%,
Proscar / Propecia has great potential for athletes who use steroids. As you know, the dihydrotestosterone metabolite is the cause of undesirable androgenic effects caused by taking testosterone. A alto nivel de dihidrotestosterona, accumulating in some tissues, causes such phenomena as oily skin, acne, growth of hair on the body and face, and alopecia. Minimizing the production of dihydrotestosterone, we reduce many side effects and stabilize the level of testosterone. In many cases, Proscar / Propecia can be combined with other steroids (such testosterone esters as cypionate, enanthate, Sustanon, etc.), halotestin y methyltestosterone, which have less androgenic capacity. Of course, do not forget that all the steroids activate the androgen receptor. Although this drug reduces androgenic activity,
It should also be noted that Avodart blocks the enzyme type 2a 5a editors. In the human body there are 2 isoenzymes, the 1st type and the 2nd. 5-a type I edema is predominant in the sebaceous glands of the skin. Enzyme 5-a editors of the second type is mainly in the prostate and hair follicle (including). Although the second type of enzyme is responsible for 2/3 dihydrotestosterone circulating in the body, a small amount of dihydrotestosterone can be produced in the body by the enzyme type 1.
Descripción del medicamento Avodart (Dutasteride)
Por lo tanto Dutasteride is effective in hair loss, and with acne and hair growth on the body and face struggles worse (these are the departments where the enzyme type 1 acts). Of course, a decrease in serum dihydrotestosterone will have un efecto beneficioso sobre los efectos secundarios. In any case, this is not a major problem, since men taking this drug, are mainly concerned with baldness. From oily skin or hair growth on the back / shoulders, you can get rid of other means or just accept it. Those who use drugs know that these problems are temporary.
And baldness can become a serious problem, often irreversible. It must also be remembered that testosterona, halotestin y methyltestosterone are the only hormones that are converted to stronger steroids with 5-alpha editors. I believe that Boldenon and methandrostenolone, too, but insignificantly. Perhaps there are other steroids that are converted to stronger metabolites via 5a reductase, but they are not currently popular. And baldness can become a serious problem, often irreversible. It must also be remembered that testosterone, halotestin and methyltestosterone are the only hormones that are converted to stronger steroids with 5-alpha editors.
Instrucciones de uso Avodart (Dutasteride)
Creo que Boldenon y metandrostenolona, too, but insignificantly. Perhaps there are other steroids that are converted to stronger metabolites via 5a reductase, but they are not currently popular. And baldness can become a serious problem, often irreversible. It must also be remembered that testosterone, halotestin and methyltestosterone are the only hormones that are converted to stronger steroids with 5-alpha editors. I believe that Boldenon and methandrostenolone, too, but insignificantly. Perhaps there are other steroids that are convertido a metabolitos más fuertes via 5a reductase, but they are not currently popular.
There is no research as to which dose will be most optimal when taking steroids. Logically, 1 tablet of 1 mg of Propecia per day is enough. In clinical practice, a single pill produces a strong effect. But if after a while the androgenic effect is too great, then you can increase the number of tablets per day or go to Proscar (5 mg tablet). Proscar / Propecia XCHARX quite expensive drugs, with an increase in the dose of their use is expensive. It may be better to keep the dosage at a minimally effective level. And the point here is not in price, but in the fact that in many cases dihidrotestosterona tiene un efecto positivo on the nervous and reproductive systems.
With a decrease in its concentration, it is possible not only for sexual disorders, but also for a decrease in strength, accumulated during the testosterone therapy (this is due to the effect of dihydrotestosterone on the neuromuscular system). In any case, when using this drug, you need to follow the advice of “use only when necessary”.
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